Soft tissue sarcoma (STS) is a relatively uncommon type of cancer and accounts for about 0.8% of all new cancer cases in the United States (US). According to an estimate, about 13040 new cases of STS and about 5150 deaths from the STS will be observed in 2018, in the US. Soft tissue sarcoma (STS) is more common among men and at an older age, with most cases reported in the individuals aged between 55 and 64 years. In the US, the overall incidence and mortality of STS have been increasing slightly with an improvement in the 5-year survival rates during the last decade. STS is a group of different neoplasms with variable characteristics and different types of cells affected. STS arises from soft tissues, such as muscle, fat, nerves, blood vessels, fibrous tissues, or deep skin tissues. STS may arise anywhere in the human body with limbs being the most common site. There are many different types of soft tissue tumors (abnormal growth of cells that remain confined to the site of origin) which are about 100 times more common than the STSs. Benign soft tissue tumors, such as fibroma, hemangioma, lipoma, leiomyoma, lymphangioma, myxoma, neurofibroma, neuroma, schwannoma, rhabdomyoma, and others are not discussed here. However, some soft tissue tumors with characteristics intermediate between cancer (abnormal growth of cells that can invade nearby tissue and can spread to distant body parts) and tumor are discussed below.

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