The lymphatic system is a part of the immune system consisting of red bone marrow, thymus, a network of lymphatic vessels, and other structures/organs like lymph nodes and spleen that are made up of lymphatic tissue (a specialized reticular tissue containing many lymphocytes or white blood cells [WBCs], which destroy the pathogens and filter out other harmful substances). The lymph (a clear liquid consisting of lymphocytes) flows through the lymphatic vessels and lymph nodes under the influence of skeletal muscle contractions and respiratory movements and finally enters the superior vena cava. The lymphatic system imparts immunity, helps in draining the interstitial fluid, and transports dietary lipids. The lymphatic system mainly consists of 2 types of lymphocytes – T-cells and B-cells. NHL is a group of different lymphoid neoplasms with variable characteristics. Most NHLs, about 80-85%, arise from the B-cells while about 15% arise from T-cells or natural killer (NK) cells. NHL may start in any part of the lymphatic system including lymph nodes, spleen, bone marrow, thymus, and gastrointestinal tract. HL mainly arises from the B-cells. HL may start in any part of the lymphatic system, but it usually starts in lymph nodes in the neck, under the arms, and in the chest.

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