Bone tumor is a relatively less common tumor type in the United States (US) accounting for about 0.2% of all new tumors and about 0.3% of all cancer-related deaths. The overall incidence of bone tumors has been increasing slightly during the last decade, while the mortality rate has been decreasing during the same time. In contrast to other cancer types, bone tumor is more common at a young age with highest incidence observed in individuals aged less than 20 years. The skeletal system provides the framework to our body, which is made up of bones and associated cartilages, ligaments, and tendons. The bones are composed of various tissues such as osseous tissue, cartilage, dense connective tissue, epithelium, adipose tissue, and nervous tissue. The osseous (bone) tissue is composed of dense extracellular matrix embedded with widely separated cells. Depending upon density, bones tissue is of two types – the compact bone tissue (present on the outer side of bones) and spongy bone tissue (forms the inner part). Periosteum is a double layer of dense connective tissue that covers the outer surface of bones. Most bones are hollow and the inner hollow cavity of bones is called as the medullary cavity that contains less dense spongy bone tissue and bone marrow. Endosteum is a single layer of connective tissue lining the medullary cavity.

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